answer:Yes, Karishma Tanna plays the lead role of Gauri in Qayamat Ki Raat. Her character is a strong-willed and confident woman who is engaged to Raj, played by Vivek Dahiya. However, her life takes a supernatural turn when a vengeful tantrik starts haunting her and her fiancé. Despite the fear and danger, Gauri remains determined to fight against the evil entity and protect her loved ones.

answer:Genomic imprinting is an epigenetic process that occurs during gametogenesis, whereby certain genes are silenced or expressed based on their parent-of-origin. This process is regulated by DNA methylation, histone modifications, and noncoding RNAs, which mark the gene according to its parental origin for transcriptional inhibition. The imprinting process is essential for normal development and function of different tissues and organs, and it plays a critical role in gene regulation and genomic stability. Imprinted genes are classified into two categories: maternally expressed, paternally silenced (MEPS) genes, and paternally expressed, maternally silenced (PEMS) genes. In MEPS genes, the maternal allele is expressed, and the paternal allele is silenced, while in PEMS genes, the paternal allele is expressed, and the maternal allele is silenced. The importance of genomic imprinting is demonstrated by the fact that mutations or abnormalities in imprinted genes can lead to a variety of genetic disorders such as Beckwith-Wiedemann syndrome and Angelman syndrome. These disorders can be caused by genetic or epigenetic changes that affect the imprinting of specific genes, leading to altered gene expression and abnormal development. In conclusion, genomic imprinting is a critical process in gene regulation that is regulated by epigenetic modifications that contribute to normal development and function of different tissues and organs. Disruption of this process can lead to genomic imprinting disorders, which can have significant impacts on health and development.

answer:Sure! Here are some examples of imprinted genes and their roles in development and disease: 1. Insulin-like growth factor 2 (IGF2): IGF2 is a maternally suppressed and paternally expressed gene, which is important for fetal growth and development. IGF2 overexpression is associated with several types of cancer, while under-expression can lead to growth disorders such as Beckwith-Wiedemann syndrome. 2. Snrpn: Snrpn is a paternally expressed gene, which plays a role in the development of the central nervous system (CNS) and the regulation of feeding behavior. Loss of Snrpn expression is linked to Prader-Willi syndrome, a rare genetic disorder that causes intellectual disability, behavioral problems, and obesity. 3. Ube3a: Ube3a is a maternally expressed gene that is involved in synaptic plasticity and learning/memory formation. Mutations in Ube3a lead to Angelman syndrome, a neurodevelopmental disorder characterized by developmental delay, seizures, and intellectual disability. 4. H19: H19 is a maternally expressed gene that regulates fetal growth and development. H19 dysregulation is associated with several types of cancer, such as hepatocellular carcinoma and bladder cancer. 5. Gnas: Gnas is a complex imprinted gene that encodes multiple protein products, including Gsα, which regulates multiple intracellular signaling pathways. Gnas mutations or dysregulation are associated with several disorders, including Albright hereditary osteodystrophy, pseudohypoparathyroidism, and McCune-Albright syndrome. These are just a few examples of imprinted genes and their roles in development and disease. The dysregulation of imprinted genes can lead to various disorders, and understanding their functions is crucial for improving diagnosis and treatment.

answer:Sure! Here are a few more examples of diseases caused by imprinted gene mutations: 1. Silver-Russell syndrome (SRS): SRS is a rare genetic disorder characterized by intrauterine growth retardation, feeding difficulties, and a range of developmental and behavioral problems. SRS has been linked to multiple imprinted genes, including H19, IGF2, GRB10, and CDKN1C. 2. Prader-Willi syndrome (PWS): PWS is a genetic disorder caused by a loss of imprinted genes on the paternally inherited chromosome 15, which leads to intellectual disability, behavioral problems, and obesity. The genes disrupted in PWS include SNRPN, NDN, and others. 3. Beckwith-Wiedemann syndrome (BWS): BWS is a rare syndrome characterized by overgrowth, abdominal wall defects, and an increased risk of developing tumors. BWS has been associated with mutations in multiple imprinted genes, including IGF2, CDKN1C, and H19. 4. Angelman syndrome (AS): AS is a rare genetic disorder caused by a loss of imprinted genes on the maternally inherited chromosome 15, which leads to intellectual disability, seizures, and a characteristic happy demeanor. The gene disrupted in AS is UBE3A. 5. Temple syndrome: Temple syndrome is a rare disorder caused by a gain of methylation at the H19/IGF2 imprinted regions, leading to growth retardation, hypoglycemia, and other features similar to SRS. These are just a few examples of diseases caused by imprinted gene mutations. The list is much longer, but these syndromes illustrate the profound effects that imprinted gene dysregulation can have on human health and development.